What does it mean when something is refractory?

1 : resisting control or authority : stubborn, unmanageable. 2a : resistant to treatment or cure a refractory lesion. b : unresponsive to stimulus. c : immune, insusceptible after recovery they were refractory to infection.

What means refractory in cancer?

Listen to pronunciation. (reh-FRAK-tor-ee KAN-ser) Cancer that does not respond to treatment. The cancer may be resistant at the beginning of treatment or it may become resistant during treatment.

What does refractory mean in construction?

The refractory is the heat-resistant material that lines high-temperature furnaces and reactors and other processing units, including commercial boilers. While refractory must be able to stand up to thermal stress, it also must be able to undergo physical wear and corrosion that comes from chemicals in the boiler.

What does chemo refractory mean?

The terms “chemorefractory” or “chemosensitive” cancer describe the responsiveness of a cancer to the drugs combating it. If a cancer responds to the chemotherapy, meaning it shrinks or vanishes after a person receives the chemo drugs, the cancer is described as “chemosensitive.”

What is the difference between relapsed and refractory?

Relapsed CLL is the term for disease that responded to therapy but, after 6 or more months, stopped responding. Refractory disease is the term for CLL that does not result in a remission (but may be stable) or disease that gets worse within 6 months of the last treatment.

How does cancer become refractory?

The meaning of refractory cancer is cancer that fails to respond to medical treatment. This may present as resistance to treatment from the start, or the acquisition of resistance by the cancer cells during the course of therapy. Refractory cancer is also called resistant cancer.

What is treatment refractory disease?

Patients with “treatment resistant” or “treatment refractory” disorders are those who do not respond to the usual first- and even second- and third-line treatments. Many people whose lives have been adversely affected by psychiatric illness struggle with a range of difficulties that may include.

What is refractory multiple myeloma?

What Is Refractory Multiple Myeloma? Multiple myeloma is a cancer that affects a type of white blood cell called a plasma cell, which helps your immune system fight infections. Refractory means your cancer doesn’t improve with treatment, or it stops responding to treatment.

What does it mean to fail chemotherapy?

Chemotherapy resistance occurs when cancers that have been responding to a therapy suddenly begin to grow. In other words, the cancer cells are resisting the effects of the chemotherapy. You may hear statements like the “cancer chemotherapy failed.” When this occurs, the drugs will need to be changed.

What are refractory mental disorders?

The Refractory Mood Disorders Program, part of the Center of Excellence on Mood Disorders, leads research in the development of innovative treatment options for refractory mood disorders. Refractory, also known as treatment-resistant, describes conditions that do not respond to at least two different medications.

What is it called when a patient does not respond to any medication for his disorder?

Specialty. Psychiatry. Treatment-resistant depression (TRD) is a term used in clinical psychiatry to describe a condition that affects people with major depressive disorder (MDD) who do not respond adequately to a course of appropriate antidepressant medication within a certain time.

Why do some patients with mental disorders fail to respond to drug therapies?

The single most significant reason why individuals with schizophrenia and bipolar disorder fail to take their medication is because of their lack of awareness of their illness (anosognosia). Other important reasons are concurrent alcohol or drug abuse; costs; and a poor relationship between psychiatrist and patient.

What is refractory anxiety?

The basic definition of treatment-refractory anxiety requires that standard anxiety disorder treatments have been successfully delivered and found to be either totally ineffective (no response) or only modestly effective (response but no remission).

Can you qualify for disability with major depressive disorder?

Depression is a mental health condition that can make many daily activities difficult. In certain cases, the symptoms of major depression can become severe enough to negatively affect your ability to work. If this is the case, you may qualify for Social Security disability benefits.

What happens when ECT doesn’t work?

If nothing else has helped, including ECT, and you are still severely depressed, you may be offered neurosurgery for mental disorder (NMD), deep brain stimulation (DBS) or vagus nerve stimulation (VNS).

What is the first line treatment for anxiety?

Selective serotonin reuptake inhibitors (SSRIs) are currently considered the first-line medication for most forms of anxiety. They work by causing more serotonin to be available in the brain, which can improve both mood and anxiety.

What medications reduce anxiety?

The most prominent of anti-anxiety drugs for the purpose of immediate relief are those known as benzodiazepines; among them are alprazolam (Xanax), clonazepam (Klonopin), chlordiazepoxide (Librium), diazepam (Valium), and lorazepam (Ativan).

Is Ket good for anxiety?

In multiple trials, those with anxious depression found that ketamine infusions were particularly effective in treating their symptoms. This indicates that ketamine is a viable treatment for those with depression and anxiety, especially cases that do not respond to traditional medications.